MicroRNAs (miRNAs) are a class of small,22nt, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They play profound and pervasive roles in manipulating gene expression involved in cell development, proliferation and apoptosis in various eukaryotes. Recently the dysregulation of miRNAs has been linked to cancer initiation and progression, indicating that miRNAs can function as tumour suppressor genes or oncogenes, leading to them being designated as oncogenic miRNAs (oncomiRs). The role of miRNAs in apoptosis is not fully understood, however, evidence is mounting that miRNAs are important in this process. The dysregulation of miRNAs involved in apoptosis may provide a mechanism for cancer development and resistance to cancer therapy. The established miRNA expression signature could be a potent tool to diagnose and treat human cancers in the future. In this report, the biosynthesis of miRNA, the mechanisms of miRNA target regulation and the involvement of miRNAs in the initiation and progression of human cancer has been discussed.
Name: Akansha
Reg.No: 1741110012
Guide Name: Dr.N.S.Raja
Date: 25.09.12
Time: 2.30 PM
Venue: 701(B)