Credit Seminar 2014: Genetic Approaches to Study Tumorigenesis in Zebrafish

Arunim Guchait ¹ ,Dr.S.Kirankumar.²
¹Student,Department of Genetic Engineering,School of Bioengineering, Kattankulathur,603-203 Tamil Nadu,India.

²Assistant Professor,Department of Genetic Engineering,School of Bioengineering, Kattankulathur,603-203 Tamil Nadu,India.

Abstract

Zebrafish is emerging as a unique model organism for studying cancer genetics and biology. For several decades zebrafish have been used to study vertebrate development, where they have made important contributions to understanding the specification and differentiation programs in many tissues. The zebrafish offers a number of features, such as its rapid development, tractable genetics, suitability for in vivo imaging and chemical screening, which make it an attractive model to cancer researchers. In this review I will provide a synopsis of the different genetic cancer models generated by the zebrafish community to date. It will discuss the use of these models to further our understanding of the mechanisms of cancer development.


Department of Genetic Engineering
SRM University