There is a historical objection against the universal validity of the second law of thermodynamics. Thermodynamic properties such as entropy are of predictive value for reactions and their directions. Cancer cells have the varied entropy against normal healthy cells. There is an entropy information flow from tumor cells to the normal cells in their vicinity. The reversal of entropy flow in coexisting normal and tumor tissues may halt the tumor development due to reversal of the signal transmission entropy in the tumor-host entity. The different entropy production rate between the normal and cancerous cells determines the direction of informational entropy current between them. There are many determining factors that regulate the direction of entropy information flow. These components are the promising targets for the cancer treatment. In this review, the determining components for the entropy information in cancerous condition will be discussed.
