Credit Seminar on Alzheimer’s Disease and Protein Misfolding

Protein misfolding is a common and intrinsic propensity of proteins that occurs continuously. Misfolding is influenced by the amino acid composition, and certain mutations are known to accelerate the process . Neurodegenerative diseases were the first described protein misfolding diseases. Among the human disorders marked by protein misfolding and aggregation, Alzheimer’s disease looms large. The brain changes believed to contribute to the development of Alzheimer’s disease are the accumulation of the protein beta amyloid outside nerve cells (neurons) in the brain and the accumulation of the protein tau inside neurons .This degeneration slowly robs its victims of their most human qualities: memory, reasoning, abstraction, and language. The microscopic lesions that Alzheimer called attention to—senile (amyloid) plaques and neurofibrillary tangles—have also provided a crucial starting point for approaching molecular pathogenesis .Here I focus on the research work done by various scientists on how protein misfolding cause Alzheimer’s disease and its various therapeutic approaches.

Name of the student : Jyothsna Rani P
Reg No: 1741210052
Batch: M.Tech II Year
Name of the Guide : Dr. Kiran kumar