The Drosophila melanogaster
is a powerful model organism which has opened new avenues in the field of
genetics and developmental Biology. Its small size, short life cycle (10-14 days)
at 250C, high reproductive rate are the main reasons for its
extensive contribution. Understanding the developmental genetics of this
organism involves knowledge about various genes that play critical role in the
development and differentiation of the organism. These developmental studies on
Drosophila melanogaster help in analyzing the function of human
disease genes, including those for neurological disorders, cancer,
cardiovascular disease, genes for the function of visual, auditory and immune
system and in future it will aid in the analysis of complex multigenic
disorders. Model animals are utilized for experimental medical science as simulation
systems. Drosophila melanogaster is a model animal whose genome have
been well characterized. Several mutant lines are available.35 novel human
genes, which have Drosophila arthologues have been implicated in segment
polarity and planar cell polarity. In 2003, huge amounts of data concerning
genome sequences, Expressed Sequence Tags (ESTs), and uncharacterized so-called
full-length cDNA have been deposited in public database. Applied bioinformatics
tools are used for the hunting of human genes homologous to Drosophila genes
with interesting phenotypes. Alzheimer Disease is a well known neurological
disorder which would arise in late forties. It is a kind of Dementia. Main
symptom is memory loss .If untreated lead to Death. Studying such a complicated
disease in Human model is highly challenging. Hence fruitfly serves as a
perfect model in studying this disease.
Name of the Student: Jayalakshmi D
Reg No: 1741210048
Batch : M.Tech II Year
Name of the Guide: Dr. Kiran kumar