Medicinal drugs do not clearly understand the mechanisms of action, especially where treatment is concerned. Identification of genes involved in drug resistance is an important step toward elucidating the genetic basis of disease and the molecular mechanism of drug action. Patients vary widely in their response to drugs. Having an understanding of the pharmacokinetic and pharmacodynamic properties of various medications is very important when assessing the ethnic differences in drug response. Genetic factors can account for 20 to 95 percent of patient variability. Genetic polymorphisms for many drug-metabolizing enzymes and drug targets (e.g: receptors) have been identified. Although currently limited to a few pathways, pharmacogenetic testing may enable physicians to understand why patients react differently to various drugs and to make better decisions about therapy. In this report I discuss in depth about the varied research done by different authors and their colleagues on the different types of genes involved and their contribution in enhancing the drug response in the patients suffering from different disorders.
Name of the Student : Sartaj Khurana
Reg No: 1741210041
Batch: M.Tech II Year
Name of the Guide : Mr N. Manoj kumar