Credit Seminar on Bone Marrow Mesenchymal Stem Cell – A Potential Therapeutic Source For Multiple Sclerosis Treatment

Multiple sclerosis (MS) is the commonest neurological cause of disability in young adults, affecting over 1.3 million people worldwide. It is a chronic multifocal and multiphasic immune mediated disorder characterized pathologically by inflammatory demyelination, axonal injury and partial remyelination. No treatments are currently available that slow, stop, or reverse disease progression in established multiple sclerosis. Stem cells have enormous potential as therapeutic tools in the treatment of neurological diseases. The multipotentiality of adult stem cells has generated much interest in their use as autologous treatments for neurological disease, since it provides a way to circumvent many of the difficulties arising from the use of embryonic stem cells. Human bone marrow-derived MSCs can be extracted relatively simply from the marrow of adult patients and maintained and expanded in culture. MSCs therefore provide an attractive and practical source of stem cells for reparative therapy in patients, and this report describes the methods for reproducible culture and neural differentiation of human MSCs generated from patient marrow.
Key words: Multiple sclerosis, Human bone marrow derived mesenchymal stem cells, Culture, Neural differentiation, Axonal injury, demyelination.

Name: Shalini RK M.Tech II Year
Reg.No: 1741110015 
Guide Name: Mrs. Rekha 
Date: 25.09.12
Time: 2.20 PM
Venue: 701(B)