Various molecular based targeting cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules involved in tumour growth and progression. Nanotechnology is the creation of useful materials, devices, and systems through the manipulation of matter on this miniscule scale. Many nanoparticles targeted therapies like nanopores, Au-nanoshells, quantum dots, cantilevers, dendrimers, Ag-nanoparitcles are used in cancer treatments. Here functionalization of gold nanoparticles (AuNPs) with both a targeting peptide (an analogue of the peptide Bombesin) and a drug peptide ligand (an analogue of the RAF peptide) with the aim of improving selectivity in the delivery of the conjugates as well as the antitumor activity is described. Studies on the internalization mechanism of peptide-AuNP conjugates and viability of cells were carried out through Confocal laser scanning microscopy, MTT assay. An enhancement of the activity and selectivity of the peptide multifunctionalized conjugates was observed.
Name: Sai Lakshmi H M.Tech II Year
Reg.No: 1741110020
Guide Name: Mrs.Rekha
Date: 25.09.12
Time: 2.20
Venue: 701(B)